2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. Lucerastat

Lucerastat  (Synonyms: NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin)

Cat. No.: HY-106392 Assay: 98.90%
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Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study.

For research use only. We do not sell to patients.

Lucerastat Chemical Structure

Lucerastat Chemical Structure

CAS No. : 141206-42-0

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Based on 1 publication(s) in Google Scholar

Lucerastat Related Antibodies

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Description

Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of glucosylceramide synthase (GCS). Lucerastat has the potential for Fabry disease study[1][2].

In Vitro

Fabry patient-derived fibroblasts with the genotypes R301G (residual -GalA activity; 20%) R220X (<3%) and W162X (<1%).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lucerastat Related Antibodies

Cell Viability Assay[2].

Cell Line: Fabry patient-derived fibroblasts with the genotypes R301G (residual-GalA activity; 20%) R220X (<3%) and W162X (<1%).
Concentration:
Incubation Time: 9 days.
Result: Dose-dependently inhibited GCS, reducing glucosylceramide and increasing sphingomyelin.
In Vivo

Lucerastat (1200 mg/kg/day food admix), a GCS inhibitor, reduces Gb3 in the absence of residual-GalA activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fabry mice (Gla-/0 and Gla-/-, n = 5 or 6 for each gender)[2].
Dosage: 1200 mg/kg/day food admix.
Administration: Food admix for 20 weeks.
Result: Reduced lipid storage in two major organs affected by FD: mean Gb3 in the kidneys (-33%, p<0.01). and α-galactose- terminated glycosphingolipids in the dorsal root ganglia (-48%, p<0.05). In the liver of the Fabry mice, mean glucosylceramide (GlcCer (24:0)) was reduced (-59%, p<0.001) in addition to Gb3 (24:1) (-37%, p<0.05) demonstrating substrate reduction through GCS inhibition.
Clinical Trial
Molecular Weight

219.28

Formula

C10H21NO4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O[C@H]1[C@@H](CO)N(CCCC)C[C@H](O)[C@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 24 mg/mL (109.45 mM; ultrasonic and warming and heat to 80°C)

DMSO : 22 mg/mL (100.33 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5604 mL 22.8019 mL 45.6038 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.90%

COA (248 KB) HNMR (621 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.5604 mL 22.8019 mL 45.6038 mL 114.0095 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL 22.8019 mL
10 mM 0.4560 mL 2.2802 mL 4.5604 mL 11.4009 mL
15 mM 0.3040 mL 1.5201 mL 3.0403 mL 7.6006 mL
20 mM 0.2280 mL 1.1401 mL 2.2802 mL 5.7005 mL
25 mM 0.1824 mL 0.9121 mL 1.8242 mL 4.5604 mL
30 mM 0.1520 mL 0.7601 mL 1.5201 mL 3.8003 mL
40 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
50 mM 0.0912 mL 0.4560 mL 0.9121 mL 2.2802 mL
60 mM 0.0760 mL 0.3800 mL 0.7601 mL 1.9002 mL
80 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
100 mM 0.0456 mL 0.2280 mL 0.4560 mL 1.1401 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lucerastat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lucerastat141206-42-0NB-DGJ N-(n-Butyl)deoxygalactonojirimycinGlucosylceramide Synthase (GCS)FabrydiseaseglucosylceramidesynthaseInhibitorinhibitorinhibit

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