1. Anti-infection
  2. Fungal
  3. Chitin synthase inhibitor 8

Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection.

For research use only. We do not sell to patients.

Chitin synthase inhibitor 8 Chemical Structure

Chitin synthase inhibitor 8 Chemical Structure

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Description

Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection[1].

IC50 & Target

Chitin synthase[1]

In Vitro

Chitin synthase inhibitor 8 (compound 9d, 300 μg/mL) inhibits chitin synthase (CHS) by 69%[1].
Chitin synthase inhibitor 8 (0.0625-0.25 μM, 24 h) shows antifungal activities[1].
Chitin synthase inhibitor 8 (32 μg/mL, 24 h) shows strong synergistic effect against A. fumigatus when combinated with Fluconazole (HY-10219) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: C. albicans, A. flavus, A. fumigatus, C. neoformans
Concentration: 1-512 μg/mL
Incubation Time: 24 h
Result: Inhibited four fungi with IC50 value of 64, 53.33, 15.08, 64 μg/mL respectively.
Molecular Weight

421.45

Formula

C23H23N3O5

SMILES

O=C(NC1=CC=CC=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Chitin synthase inhibitor 8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Chitin synthase inhibitor 8
Cat. No.:
HY-151418
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