7-Nitroindazole sodium
Based on 1 publication(s) in Google Scholar
7-Nitroindazole sodium is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties.
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- CAS No.: 161467-34-1
- Formula: C7H4N3NaO2
- Molecular Weight:185.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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ARL 17477 (Standard)Reference Standard
Publications Citing Use of MedChemExpress (MCE) 7-Nitroindazole sodium
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Biological Activity
Description
Chemical Information
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CAS No. 161467-34-1
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Molecular Weight 185.12
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Formula C7H4N3NaO2
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SMILES
O=[N+](C1=CC=CC2=C1[N-]N=C2)[O-].[Na+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
R-(+)-WIN55212-2 protects pericytes from ischemic damage and restores retinal microcirculatory patency after ischemia/reperfusion injury. [Abstract]2023 Oct:166:115197. PMID: 37572634
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7. [Content Brief]
[2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7-Nitroindazole sodium Related Classifications
HY-69019A Related Classifications
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