161467-34-1
161467-34-1
Chemical Structure
7-Nitroindazole sodium
- CAS. Nr.: 161467-34-1
- Formula:C7H4N3NaO2
- Molecular Weight:185.12
IUPAC Name: sodium 7-nitroindazol-1-ide
InChIKey: DJMLKKIIBMJGIQ-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=CC2=C1[N-]N=C2)[O-].[Na+]
Biological Activity: 7-Nitroindazole sodium is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties[1][2].
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7-Nitroindazole sodium | 7-Nitroindazole sodium is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties. | |||||||||||||||||||||
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References
- [1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7. [Content Brief]
- [2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24. [Content Brief]
Keywords
