2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK3-IN-9

GSK3-IN-9 (Compound 0713) is a selective glycogen synthase kinase 3 (GSK3) inhibitor. GSK3-IN-9 Fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood seizure, intellectual disability, diabetes, acute myeloid leukemia (AML), autism, and psychiatric disorder.

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GSK3-IN-9

GSK3-IN-9 Chemical Structure

CAS No. : 748145-12-2

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Based on 1 publication(s) in Google Scholar

GSK3-IN-9 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

GSK3-IN-9 (Compound 0713) is a selective glycogen synthase kinase 3 (GSK3) inhibitor. GSK3-IN-9 Fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood seizure, intellectual disability, diabetes, acute myeloid leukemia (AML), autism, and psychiatric disorder[1].

Molecular Weight

308.38

Formula

C18H20N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C2C(N=C3CC(C)(CC(C3C2C4=CC=CC=N4)=O)C)=NN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (13.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2428 mL 16.2138 mL 32.4275 mL
5 mM 0.6486 mL 3.2428 mL 6.4855 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2428 mL 16.2138 mL 32.4275 mL 81.0688 mL
5 mM 0.6486 mL 3.2428 mL 6.4855 mL 16.2138 mL
10 mM 0.3243 mL 1.6214 mL 3.2428 mL 8.1069 mL
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GSK3-IN-9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3-IN-9748145-12-2GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3GSK3ADHDAMLInhibitorinhibitorinhibit

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