SDMA-d₆ (Synonyms: Symmetric dimethylarginine-d₆; NG,NG'-Dimethyl-L-arginine-d₆)

Name: SDMA-d 6
Brand: MedChemExpress
SKU: HY-101410S
Rating: 4.5 (1 reviews)

Cat. No.: HY-101410S Purity: 98.07%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

SDMA-d₆ is the deuterium labeled SDMA. SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity[1][2].

For research use only. We do not sell to patients.

SDMA-d₆ Chemical Structure

CAS No. : 1331888-08-4

Size	Stock	Quantity
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Description

SDMA-d₆ is the deuterium labeled SDMA. SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

208.29

Formula

C₈H₁₂D₆N₄O₂

CAS No.

1331888-08-4

Unlabeled CAS

30344-00-4

Appearance

Solid

Color

White to light yellow

SMILES

OC([C@@H](N)CCC/N=C(NC([2H])([2H])[2H])/NC([2H])([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (240.05 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8010 mL	24.0050 mL	48.0100 mL
5 mM	0.9602 mL	4.8010 mL	9.6020 mL
10 mM	0.4801 mL	2.4005 mL	4.8010 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.07%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Bode-Böger SM,et al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent ofcoronary artery disease. [Content Brief]

[3]. Schepers E, et al. Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.Clin J Am Soc Nephrol. 2011 Oct;6(10):2374-83. [Content Brief]

[4]. Nabity MB, et al. Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the EarlyDetection of Chronic Kidney Disease in Dogs. J Vet Intern Med. 2015 Jul-Aug;29(4):1036-44. [Content Brief]

[5]. Veldink H, et al. Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice. Nephrol Dial Transplant. 2013 Jun;28(6):1434-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.8010 mL	24.0050 mL	48.0100 mL	120.0250 mL
	5 mM	0.9602 mL	4.8010 mL	9.6020 mL	24.0050 mL
	10 mM	0.4801 mL	2.4005 mL	4.8010 mL	12.0025 mL
	15 mM	0.3201 mL	1.6003 mL	3.2007 mL	8.0017 mL
	20 mM	0.2400 mL	1.2002 mL	2.4005 mL	6.0012 mL
	25 mM	0.1920 mL	0.9602 mL	1.9204 mL	4.8010 mL
	30 mM	0.1600 mL	0.8002 mL	1.6003 mL	4.0008 mL
	40 mM	0.1200 mL	0.6001 mL	1.2002 mL	3.0006 mL
	50 mM	0.0960 mL	0.4801 mL	0.9602 mL	2.4005 mL
	60 mM	0.0800 mL	0.4001 mL	0.8002 mL	2.0004 mL
	80 mM	0.0600 mL	0.3001 mL	0.6001 mL	1.5003 mL
	100 mM	0.0480 mL	0.2400 mL	0.4801 mL	1.2002 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

SDMA-d₆ Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDMA-d₆1331888-08-4Symmetric dimethylarginine-d₆NG,NG'-Dimethyl-L-arginine-d₆Endogenous MetaboliteInhibitorinhibitorinhibit

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SDMA-d6 (Synonyms: Symmetric dimethylarginine-d6; NG,NG'-Dimethyl-L-arginine-d6)

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SDMA-d₆ (Synonyms: Symmetric dimethylarginine-d₆; NG,NG'-Dimethyl-L-arginine-d₆)

Other Forms of SDMA-d₆:

SDMA-d₆ Related Antibodies

SDMA-d₆ Related Antibodies

SDMA-d₆ Related Classifications