2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. JGK-263

JGK-263 is an orally active Glycogen synthase kinase-3β (GSK-3β) inhibitor. JGK-263 exhibits neuroprotective effect and can improve motor function. JGK-263 can be used for the research of neurological disease, such as amyotrophic lateral sclerosis (ALS).

For research use only. We do not sell to patients.

JGK-263

JGK-263 Chemical Structure

CAS No. : 1408054-46-5

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JGK-263 Related Antibodies

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Description

JGK-263 is an orally active Glycogen synthase kinase-3β (GSK-3β) inhibitor. JGK-263 exhibits neuroprotective effect and can improve motor function. JGK-263 can be used for the research of neurological disease, such as amyotrophic lateral sclerosis (ALS)[1].

IC50 & Target[1]

GSK-3β

 

In Vivo

JGK-263 (20-50 mg/kg, p.o.) remarkably improves motor function and prolongs the time until symptom onset, rotarod failure, and death in transgenic mice with ALS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

303.75

Formula

C14H14ClN5O
CAS No.
SMILES

O=C1NN=C2C(NCCCC3=CC=NC=C3)=CC(Cl)=CN21
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JGK-263 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JGK-2631408054-46-5JGK263JGK 263GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3Glycogen synthase kinase-3βGSK-3βneuroprotectiveamyotrophic lateral sclerosisALSInhibitorinhibitorinhibit

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