country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182529

Copy Link Print Information

DHPS-IN-3

DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC₅₀ of 0.0092 μM at 14 μM NAD and an IC₅₀ of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2470012-40-7
Formula: C₁₈H₂₃N₃OS
Molecular Weight:329.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DHPS-IN-3 Chemical Structure

CAS No.: 2470012-40-7

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC₅₀ of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	V_dss	CL_total	C_max	MRT	F
Mice^[1]	0.1 mg/kg	i.v.	8491 mL/kg	8965 mL/h/kg	/	/	/
Mice^[1]	1 mg/kg	p.o.	/	/	4.8 ng/mL	2.46 h	11.7 %

Chemical Information

CAS No. 2470012-40-7
Molecular Weight 329.46
Formula C₁₈H₂₃N₃OS
SMILES

O=C1C2=C(CCN1[C@@H](CN)CC(C)C)C(C3=CN=CC=C3)=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tanaka Y, et al. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett. 2020;11(8):1645-1652. Published 2020 Jul 30. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock