CYP11B2-IN-2
CYP11B2-IN-2 (Compound 10k) is an inhibitor for enzyme aldosterone synthase CYP11B2 with an IC50 of 0.3 nM. CYP11B2-IN-2 CYP11B-IN-2 is labeled with 18F and can be used as a positron emission tomography (PET) tracer for the diagnosis of primary aldosteronism.
For research use only. We do not sell to patients.
- CAS No.: 2241573-22-6
- Formula: C16H13FN2O2
- Molecular Weight:284.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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CYP11B2 0.3 nM (IC50) |
CYP11B1 3.8 nM (IC50) |
Chemical Information
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CAS No. 2241573-22-6
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Molecular Weight 284.29
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Formula C16H13FN2O2
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SMILES
FC1=CC(C2=CC(C3(C)OCCO3)=CN=C2)=CC=C1C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP11B2-IN-2 Related Classifications
HY-162574 Related Classifications
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