JMF4073
JMF4073 is a thymidylate (TMP) and cytidylate (CMP) kinases inhibitor with IC50s of 0.16 μM and 0.17 μM, respectively. JMF4073 eliminates wild-type (WT)-Bcr-Abl-transformed myeloid cells in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 1927930-61-7
- Formula: C18H22FN3O4S
- Molecular Weight:395.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
WT-Bcr-Abl cells are highly susceptible to JMF4073 with GI50 0.67 μM as compared to 1.5 μM and 4.2 μM for T315I-Bcr-Abl-32D and untransformed 32D cells, respectively. The levels of overall tyrosine phosphorylation in these cells were unaffected by JMF4073 treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C3H/HeNCrNarl mice injected with WT-Bcr-Abl-32D chronic myeloid leukemia (CML) cells[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; daily; for 14 days
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Result:Prolonged the survival of leukemia mice.
Chemical Information
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CAS No. 1927930-61-7
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Molecular Weight 395.45
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Formula C18H22FN3O4S
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SMILES
FC1=CC=C(SN(CC(N2CCN(C(OC(C)(C)C)=O)CC2)=O)C3=O)C3=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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