DF 461
DF 461 is a sterol synthase inhibitor with significant inhibitory activity. DF 461 shows high selectivity for the liver and can effectively inhibit cholesterol synthesis in rat liver. DF 461 has shown the effect of lowering plasma lipids in repeated dosing studies in non-rodents.
For research use only. We do not sell to patients.
- CAS No.: 937051-40-6
- Formula: C20H14Cl2F3N3O4
- Molecular Weight:488.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
19 nM
Compound: 23, DF-461
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Inhibition of cholesterol synthesis in rat hepatocytes assessed as formation of cholesterol using [14C]mevalonolactone as substrate after 1 hr by liquid scintillation counting
Inhibition of cholesterol synthesis in rat hepatocytes assessed as formation of cholesterol using [14C]mevalonolactone as substrate after 1 hr by liquid scintillation counting
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[PMID: 24900587] |
Chemical Information
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CAS No. 937051-40-6
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Molecular Weight 488.24
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Formula C20H14Cl2F3N3O4
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SMILES
O=C(O)C[C@@H]1C2=NN=C(C(F)(F)F)N2C3=CC=C(Cl)C=C3[C@@H](C4=CC=CC(OC)=C4Cl)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)