Chitin synthase inhibitor 6 

Chitin synthase inhibitor 6 (compound 9b) is a potent chitin synthase (CHS) inhibitor with an IC₅₀ value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection^[1].

Chitin synthase inhibitor 6 (compound 9b; 300 μg/mL) inhibits chitin synthase (CHS) activity with an inhibition percentage (IP) value of 82%^[1].
Chitin synthase inhibitor 6 (1-512 μg/mL) has antifungal activity against four strains with minimum inhibitory concentration (MIC) values of 64, 64, 128, and 256 μg/mL for C. albicans, A. flavus, A. fumigatus, and C. neoformans, respectively^[1].
Chitin synthase inhibitor 6 (0-256 μg/mL (50 μL), 24 h) shows strong synergistic effect against A. fumigatus when combinated with Fluconazole (HY-10219). Chitin synthase inhibitor 6 and fluconazole combination against C. neoformans (FIC = 0.625) and additive effect against C. albicans (FIC = 1.10). A. fumigatus (FIC = 1.125)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

451.47

C₂₄H₂₅N₃O₆

O=C(NC1=CC=C(OC)C=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu Y, et, al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723.  [Content Brief]