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Cat. No.: HY-151416

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Chitin synthase inhibitor 6

Chitin synthase inhibitor 6 (compound 9b) is a potent chitin synthase (CHS) inhibitor with an IC₅₀ value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection.

For research use only. We do not sell to patients.

CAS No.: 3033645-29-0
Formula: C₂₄H₂₅N₃O₆
Molecular Weight:451.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Chitin synthase inhibitor 6 Chemical Structure

CAS No.: 3033645-29-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Chitin synthase inhibitor 6 (compound 9b; 300 μg/mL) inhibits chitin synthase (CHS) activity with an inhibition percentage (IP) value of 82%^[1].
Chitin synthase inhibitor 6 (1-512 μg/mL) has antifungal activity against four strains with minimum inhibitory concentration (MIC) values of 64, 64, 128, and 256 μg/mL for C. albicans, A. flavus, A. fumigatus, and C. neoformans, respectively^[1].
Chitin synthase inhibitor 6 (0-256 μg/mL (50 μL), 24 h) shows strong synergistic effect against A. fumigatus when combinated with Fluconazole (HY-10219). Chitin synthase inhibitor 6 and fluconazole combination against C. neoformans (FIC = 0.625) and additive effect against C. albicans (FIC = 1.10). A. fumigatus (FIC = 1.125)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3033645-29-0
Molecular Weight 451.47
Formula C₂₄H₂₅N₃O₆
SMILES

O=C(NC1=CC=C(OC)C=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Y, et, al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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