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Cat. No.: HY-126825

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NE21650

NE21650 potently inhibits farnesyl diphosphate (FPP) synthase. NE21650 is a weak inhibitor of isopentenyl diphosphate (IPP) isomerase. NE21650 is a potent inhibitor of protein prenylation in osteoclasts and macrophages and bone resorption in vitro.

For research use only. We do not sell to patients.

CAS No.: 427899-21-6
Formula: C₈H₁₃NO₇P₂
Molecular Weight:297.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

NE21650 Chemical Structure

CAS No.: 427899-21-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	205 μM Compound: 27	Toxicity against human MCF7 cells assessed as growth inhibition by broth microdilution method Toxicity against human MCF7 cells assessed as growth inhibition by broth microdilution method	[PMID: 18789701]
NCI-H460	IC₅₀	187 μM Compound: 27	Toxicity against human NCI-H460 cells assessed as growth inhibition by broth microdilution method Toxicity against human NCI-H460 cells assessed as growth inhibition by broth microdilution method	[PMID: 18789701]
SF-268	IC₅₀	186 μM Compound: 27	Toxicity against human SF268 cells assessed as growth inhibition by broth microdilution method Toxicity against human SF268 cells assessed as growth inhibition by broth microdilution method	[PMID: 18789701]

Chemical Information

CAS No. 427899-21-6
Molecular Weight 297.14
Formula C₈H₁₃NO₇P₂
SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CC1=CC=CC=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keith Thompson, et al. Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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