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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. HMBS Antibody (YA3061)

HMBS Antibody (YA3061) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMBS.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

HMBS Antibody (YA3061) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMBS.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 39 kDa;
Observed band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human HMBS aa300-361/361.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18004775, PubMed:18936296, PubMed:19138865, PubMed:23815679). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled (PubMed:18936296). In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296)
Subcellular Localization：Cytoplasm, cytosol
Expression：
Tissue_specificity:Is ubiquitously expressed; Is found only in erythroid cells
Isoforms & Post-Translational Modification：P08397 has 4 isomers: P08397-1: 39330 Da (predicted); P08397-2: 37699 Da (predicted); P08397-3: 34895 Da (predicted); P08397-4: 33264 Da (predicted).
Subunit：Monomer
Database

Entrez Gene: 3145 Human ; 15288 Mouse ;

SwissProt: P08397 Human ; P22907 Mouse ; P19356 Rat

OMIM: 176000 Human

Research Field

Signal Transduction
Synonyms
UPS; PBGD; PORC; PBG-D; HMBS; Hydroxymethylbilane synthase
Documentation
User Guide for Antibodies (1077 KB)

HMBS Antibody (YA3061) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HMBS Antibody (YA3061)
Cat. No.:
HY-P83316
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