1. Anti-infection
  2. Bacterial
  3. ML406

ML406 

Cat. No.: HY-124781
Handling Instructions

ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM.

For research use only. We do not sell to patients.

ML406 Chemical Structure

ML406 Chemical Structure

CAS No. : 774589-47-8

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Description

ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM[1].

IC50 & Target

IC50 30 nM (BioA)[1]

In Vitro

ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB)[1].

Molecular Weight

352.38

Formula

C₂₀H₂₀N₂O₄

CAS No.

774589-47-8

SMILES

CC(C1=CC=C(N2CCN(C(C3=CC=C(OCO4)C4=C3)=O)CC2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ML406ML 406ML-406Bacterialanti-tubercularbioADAPAsynthaseMycobacteriumtuberculosisInhibitorinhibitorinhibit

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