774589-47-8
774589-47-8
Chemical Structure
ML406
- CAS. Nr.: 774589-47-8
- Formula:C20H20N2O4
- Molecular Weight:352.38
IUPAC Name: 1-(4-(4-(benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethan-1-one
InChIKey: DMJGPASMZSNEAZ-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(N2CCN(C(C3=CC=C(OCO4)C4=C3)=O)CC2)C=C1)=O
Biological Activity: ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis[1].
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ML406 | 98.55% | ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis. | ||||||||||||||||||||
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ML406 (Standard) | ≥98% | ML406 (Standard) is the analytical standard of ML406. This product is intended for research and analytical applications. ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis. | ||||||||||||||||||||
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References
- [1]. Casalena D, et al. Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition. 2014 Apr 15 [updated 2015 Jan 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. [Content Brief]
