DS55980254
Based on 1 Customer Validation
DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 2488609-43-2
- Formula: C29H18F8N4O4
- Molecular Weight:638.46
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Phospholipase Isoforms
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Biological Activity
phosphatidylserine synthase 1 (PTDSS1)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Jeko-1 xenograft mouse model[2]
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Dosage:10-100 mg/kg
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Administration:po, once daily for 21 days
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Result:Inhibited the colonization of Jeko-1 cells in the mouse bone marrow, prolonged the mouse survival.
Chemical Information
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CAS No. 2488609-43-2
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Appearance Solid
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Molecular Weight 638.46
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Formula C29H18F8N4O4
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Color White to off-white
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SMILES
FC(C)(CN1[C@](C2=CC=C(OC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C=C2)([H])C4=C(C5=CC=CC(N6)=C5OC6=O)NN=C4C1=O)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 200 mg/mL (313.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (7.83 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5663 mL | 7.8313 mL | 15.6627 mL | 39.1567 mL |
| 5 mM | 0.3133 mL | 1.5663 mL | 3.1325 mL | 7.8313 mL | |
| 10 mM | 0.1566 mL | 0.7831 mL | 1.5663 mL | 3.9157 mL | |
| 15 mM | 0.1044 mL | 0.5221 mL | 1.0442 mL | 2.6104 mL | |
| 20 mM | 0.0783 mL | 0.3916 mL | 0.7831 mL | 1.9578 mL | |
| 25 mM | 0.0627 mL | 0.3133 mL | 0.6265 mL | 1.5663 mL | |
| 30 mM | 0.0522 mL | 0.2610 mL | 0.5221 mL | 1.3052 mL | |
| 40 mM | 0.0392 mL | 0.1958 mL | 0.3916 mL | 0.9789 mL | |
| 50 mM | 0.0313 mL | 0.1566 mL | 0.3133 mL | 0.7831 mL | |
| 60 mM | 0.0261 mL | 0.1305 mL | 0.2610 mL | 0.6526 mL | |
| 80 mM | 0.0196 mL | 0.0979 mL | 0.1958 mL | 0.4895 mL | |
| 100 mM | 0.0157 mL | 0.0783 mL | 0.1566 mL | 0.3916 mL |
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