2488609-43-2
2488609-43-2
Chemical Structure
DS55980254
- CAS No.: 2488609-43-2
- Formula:C29H18F8N4O4
- Molecular Weight:638.46
InChIKey: OFKFAYQYNRXLHR-QHCPKHFHSA-N
SMILES: FC(C)(CN1[C@](C2=CC=C(OC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C=C2)([H])C4=C(C5=CC=CC(N6)=C5OC6=O)NN=C4C1=O)F
Biological Activity: DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway[1][2].
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DS55980254 | 99.25% | DS55980254 is the orally active inhibitor for phosphatidylserine synthase 1 (PTDSS1) that blocks the synthesis of intracellular phosphatidylserine. PTDSS1 deficiency affects the balance of cell membrane phospholipid components, and activates B cell receptor (BCR) signaling pathway. | ||||||||||||||||||||
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References
- [1]. Keisuke Suzuki, et al. Efficient Multikilogram-Scale Synthesis of PTDSS1 Inhibitor: Development of a Practical and Scalable Optical Resolution Method for Chiral 2,3-Pyrrolidinedione. Org. Process Res. Dev. 2024.
- [2]. Omi J, et al., Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma. J Cell Biol. 2024 Feb 5;223(2):e202212074. [Content Brief]
