L-NIL dihydrochloride
Based on 10 publication(s) in Google Scholar
L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.
For research use only. We do not sell to patients.
- CAS No.: 159190-45-1
- Formula: C8H19Cl2N3O2
- Molecular Weight:260.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-NIL dihydrochloride
More- Nat Biomed Eng. 2023 Mar;7(3):281-297. [Abstract]
- Nat Commun. 2025 Jul 1;16(1):5547. [Abstract]
- J Adv Res. 2023 Jan:43:175-186. [Abstract]
- Sci Transl Med. 2025 May 21;17(799):eadn7527. [Abstract]
- Cancer Lett. 2023 Aug 28:570:216330. [Abstract]
- Free Radic Biol Med. 2023 May 1:200:73-86. [Abstract]
- J Agric Food Chem. 2024 May 16. [Abstract]
- Exp Eye Res. 2024 Jun:243:109886. [Abstract]
- Biochem Biophys Res Commun. 2024 Aug 22:734:150589. [Abstract]
- bioRxiv. 2026 Jun 13:2026.06.12.731980. [Abstract]
Customer Validation & Images
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Biological Activity
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iNOS |
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Balb/c (20-25 g)[1].
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Dosage:10 and 30 mg/kg.
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Administration:Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
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Result:Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
Chemical Information
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CAS No. 159190-45-1
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Molecular Weight 260.16
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Formula C8H19Cl2N3O2
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SMILES
N[C@@H](CCCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Biomed Eng
Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine. [Abstract]2023 Mar;7(3):281-297. PMID: 36941352 -
Nat Commun
Host glutathione is required for Rickettsia parkeri cell division and intracellular survival. [Abstract]2025 Jul 1;16(1):5547. PMID: 40593553 -
J Adv Res
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation. [Abstract]2023 Jan:43:175-186. PMID: 36585107
L-NIL dihydrochloride purchased from MedChemExpress. Usage Cited in: J Adv Res. 2023 Jan:43:175-186. [Abstract]
Inhibiting iNOS with L-NIL (10 μM) blunted the adverse effect of iNOS expression in cardiomyocytes.
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Sci Transl Med
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19. [Abstract]2025 May 21;17(799):eadn7527. PMID: 40397714 -
Cancer Lett
Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGFβ-dependent squamous cell carcinoma lung metastasis. [Abstract]2023 Aug 28:570:216330. PMID: 37524225 -
Free Radic Biol Med
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis. [Abstract]2023 May 1:200:73-86. PMID: 36871899 -
J Agric Food Chem
Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis. [Abstract]2024 May 16. PMID: 38755521 -
Exp Eye Res
2024 Jun:243:109886. PMID: 38583755 -
Biochem Biophys Res Commun
Exploring the role of iNOS in HFpEF-Related myocardial fibrosis: Involvement of PTEN-PI3K/AKT signaling pathway. [Abstract]2024 Aug 22:734:150589. PMID: 39245028 -
bioRxiv
A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes. [Abstract]2026 Jun 13:2026.06.12.731980. PMID: 42327330
Purity & Documentation
References
[1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. [Content Brief]
[2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. [Content Brief]
[3]. W M Moore, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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