1. Immunology/Inflammation
  2. NO Synthase
  3. L-NIL dihydrochloride

L-NIL dihydrochloride 

Cat. No.: HY-12118
Handling Instructions

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.

For research use only. We do not sell to patients.

L-NIL dihydrochloride Chemical Structure

L-NIL dihydrochloride Chemical Structure

CAS No. : 159190-45-1

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Description

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].

IC50 & Target

IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[3].

In Vitro

L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2].

In Vivo

L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].

Animal Model: Adult male Balb/c (20-25 g)[1].
Dosage: 10 and 30 mg/kg.
Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
Result: Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
Molecular Weight

260.16

Formula

C₈H₁₉Cl₂N₃O₂

CAS No.

159190-45-1

SMILES

N[[email protected]@H](CCCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

L-NILNO SynthaseNitric oxide synthasesNOSNLRP3InflammasomeAcuteKidneyInjuryPolymicrobialSepsisAKIIL-1βInhibitorinhibitorinhibit

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Product Name:
L-NIL dihydrochloride
Cat. No.:
HY-12118
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