2. Immunology/Inflammation
  3. NO Synthase
  4. L-NIL dihydrochloride

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.

For research use only. We do not sell to patients.

L-NIL dihydrochloride Chemical Structure

L-NIL dihydrochloride Chemical Structure

CAS No. : 159190-45-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of L-NIL dihydrochloride:

Other Forms of L-NIL dihydrochloride:

L-NIL dihydrochloride Related Antibodies

Top Publications Citing Use of Products

    L-NIL dihydrochloride purchased from MedChemExpress. Usage Cited in: J Adv Res. 5 March 2022.

    Inhibiting iNOS with L-NIL (10 μM) blunted the adverse effect of iNOS expression in cardiomyocytes.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].

    IC50 & Target

    IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[3].
    In Vitro

    L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-NIL dihydrochloride Related Antibodies
    In Vivo

    L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Balb/c (20-25 g)[1].
    Dosage: 10 and 30 mg/kg.
    Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
    Result: Led to a negligible increase in plasma NGAL compared to sham mice.
    Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
    Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
    Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
    Molecular Weight

    260.16

    Formula

    C8H19Cl2N3O2
    CAS No.
    SMILES

    N[C@@H](CCCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    L-NIL dihydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-NIL159190-45-1NO SynthaseNitric oxide synthasesNOSNLRP3InflammasomeAcuteKidneyInjuryPolymicrobialSepsisAKIIL-1βInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email Address *

    Phone Number *

    		 

    Organization Name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    L-NIL dihydrochloride
    Cat. No.:
    HY-12118
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.