159190-45-1
159190-45-1
Chemical Structure
L-NIL dihydrochloride
- CAS. Nr.: 159190-45-1
- Formula:C8H19Cl2N3O2
- Molecular Weight:260.16
IUPAC Name: N6-(1-iminoethyl)-L-lysine dihydrochloride
InChIKey: OQIBCXRAFAHXMM-KLXURFKVSA-N
SMILES: N[C@@H](CCCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl
Biological Activity: L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].
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L-NIL dihydrochloride | L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS. | |||||||||||||||||||||
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References
- [1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. [Content Brief]
- [2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. [Content Brief]
- [3]. W M Moore, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. [Content Brief]
