2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. PGE synthase Lipoxygenase
  4. 6,9,12,15,18-Heneicosapentaenoic acid

6,9,12,15,18-Heneicosapentaenoic acid  (Synonyms: HPA; Heneicosapentaenoic acid methyl ester)

Cat. No.: HY-141469 Purity: 99.4%
COA
SDS
Handling Instructions Technical Support

6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer.

For research use only. We do not sell to patients.

6,9,12,15,18-Heneicosapentaenoic acid

6,9,12,15,18-Heneicosapentaenoic acid Chemical Structure

CAS No. : 65919-53-1

Size Price Stock Quantity
Solvent
1 mg (30.26 mM * 100 μL in Ethanol) In-stock
Solvent
5 mg (30.26 mM * 500 μL in Ethanol) In-stock

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

6,9,12,15,18-Heneicosapentaenoic acid Related Antibodies

Top Publications Citing Use of Products

View All Lipoxygenase Isoform Specific Products:

View All Isoforms
5-LOX 12-LOX 15-LOX

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer[1][2].

IC50 & Target[1]

5-Lipoxygenase

 

In Vitro

6,9,12,15,18-Heneicosapentaenoic acid (50 µM; 4 h) potently inhibits Δ5 desaturase activity in 7800 C1 Morris hepatoma cells, reducing the conversion efficiency of dihomo-γ-linolenic acid to arachidonic acid to 3.3% of the incorporated substrate, and its inhibitory effect is stronger than that of EPA, DHA or arachidonic acid[1].
6,9,12,15,18-Heneicosapentaenoic acid (25 µM; 15 min at 37°C) exerts no significant inhibitory effect on Δ6 desaturase activity in isolated rat liver microsomes, with the yield of γ-linolenic acid reaching 6.7% of the added linoleic acid[1].
6,9,12,15,18-Heneicosapentaenoic acid (10 µM; 4 min incubation) inhibits thromboxane B2 production in isolated platelets as effectively as EPA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6,9,12,15,18-Heneicosapentaenoic acid Related Antibodies
Molecular Weight

330.50

Formula

C22H34O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCC(OC)=O
Structure Classification
Initial Source

fish oils
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 99.4%

SDS (393 KB)

COA (237 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

6,9,12,15,18-Heneicosapentaenoic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,9,12,15,18-Heneicosapentaenoic acid65919-53-1HPA Heneicosapentaenoic acid methyl esterPGE synthaseLipoxygenaseProstaglandin E synthaseLOXsheep?5 desaturasehepatomarat hepatocyteprostaglandin H synthaseacyl-CoA oxidasearachidonic acid7800 C1 Morris hepatoma cellthromboxane synthesis5-lipoxygenaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
6,9,12,15,18-Heneicosapentaenoic acid
Cat. No.:
HY-141469
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.