2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. PGE synthase Lipoxygenase
  4. 6,9,12,15,18-Heneicosapentaenoic acid

6,9,12,15,18-Heneicosapentaenoic acid  (Synonyms: HPA; Heneicosapentaenoic acid methyl ester)

Cat. No.: HY-141469 Purity: 99.4%
COA
SDS
Handling Instructions Technical Support

6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer.

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6,9,12,15,18-Heneicosapentaenoic acid

6,9,12,15,18-Heneicosapentaenoic acid 화학구조

CAS No. : 65919-53-1

사이즈 가격 재고 수량
Solvent
1 mg (30.26 mM * 100 μL in Ethanol) 해외재고보유
Solvent
5 mg (30.26 mM * 500 μL in Ethanol) 해외재고보유

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6,9,12,15,18-Heneicosapentaenoic acid Related Antibodies

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제품 설명

6,9,12,15,18-Heneicosapentaenoic acid (HPA) is a ∆5 desaturase inhibitor. 6,9,12,15,18-Heneicosapentaenoic acid serves as a weak substrate for Prostaglandin H synthase and 5-lipoxygenase, yet it inactivates Prostaglandin H synthase at a rate comparable to that of AA, EPA and DHA. 6,9,12,15,18-Heneicosapentaenoic acid is a weak inducer of Aacyl-CoA oxidase. 6,9,12,15,18-Heneicosapentaenoic acid incorporates into phospholipids and triacylglycerols in cell culture. 6,9,12,15,18-Heneicosapentaenoic acid can be used in research related to liver cancer[1][2].

IC50 & Target[1]

5-Lipoxygenase

 

In Vitro

6,9,12,15,18-Heneicosapentaenoic acid (50 µM; 4 h) potently inhibits Δ5 desaturase activity in 7800 C1 Morris hepatoma cells, reducing the conversion efficiency of dihomo-γ-linolenic acid to arachidonic acid to 3.3% of the incorporated substrate, and its inhibitory effect is stronger than that of EPA, DHA or arachidonic acid[1].
6,9,12,15,18-Heneicosapentaenoic acid (25 µM; 15 min at 37°C) exerts no significant inhibitory effect on Δ6 desaturase activity in isolated rat liver microsomes, with the yield of γ-linolenic acid reaching 6.7% of the added linoleic acid[1].
6,9,12,15,18-Heneicosapentaenoic acid (10 µM; 4 min incubation) inhibits thromboxane B2 production in isolated platelets as effectively as EPA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6,9,12,15,18-Heneicosapentaenoic acid Related Antibodies
분자량

330.50

화학식

C22H34O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCC(OC)=O
Structure Classification
Initial Source

fish oils
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years
순도&문서

Purity: 99.4%

SDS (393 KB)

COA (237 KB)

Handling Instructions (2659 KB)
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6,9,12,15,18-Heneicosapentaenoic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,9,12,15,18-Heneicosapentaenoic acid65919-53-1HPA Heneicosapentaenoic acid methyl esterPGE synthaseLipoxygenaseProstaglandin E synthaseLOXsheep?5 desaturasehepatomarat hepatocyteprostaglandin H synthaseacyl-CoA oxidasearachidonic acid7800 C1 Morris hepatoma cellthromboxane synthesis5-lipoxygenaseInhibitorinhibitorinhibit

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상품명:
6,9,12,15,18-Heneicosapentaenoic acid
Cat. No.:
HY-141469
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