Fatty Acid Estolides

Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC₅₀ of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids.

9-PAHSA is an orally active endogenous GPR120 agonist (EC₅₀=18 μM). 9-PAHSA significantly inhibits LPS-induced inflammatory responses by blocking the NF-κB pathway. 9-PAHSA induces adipocyte browning, enhances glucose uptake and reduces lipid accumulation, while improving mitochondrial function and the survival rate of steatotic hepatocytes. In terms of neuroprotection, 9-PAHSA regulates the expression of REST and BDNF in the prefrontal cortex of diabetic mice, and effectively prevents spatial working memory deficits and abnormal social behaviors. 9-PAHSA does not directly regulate insulin secretion or improve systemic insulin sensitivity, and possesses specific anti-inflammatory, metabolic regulatory and neuroprotective properties. 9-PAHSA can be used in the research of diabetes-related cognitive impairment, obesity and non-alcoholic fatty liver disease.

Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects.

Royal Jelly Acid ((E)-Queen Bee Acid) is a major fatty acid found in royal jelly with oral bioavailability, exhibiting anti-inflammatory, anticancer, antimalarial, antiprotozoal, and neuroregulatory activities. Royal Jelly Acid can be used for research in various fields, including cancer, infections, immune inflammation, and neurological diseases.

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins.

BML-111, a lipoxin A₄ analog, is a lipoxin A₄ receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties.

Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC₅₀ = 0.12 μM). Hymeglusin covalently modifies the active Cys¹²⁹ residue of the enzyme.

Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics

11-Mercaptoundecanoate-NHS is a lipid that can be used for the synthesis of Linker.

5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics.

Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC₅₀ of 70 μM. Anti-melanogenesis Effects.

Suberic acid monomethyl ester is an ester product. Suberic acid monomethyl ester is a PROTAC linker that can be used in the synthesis of PROTACs, DDD2 (HY-176261).

2-Hydroxystearic acid is an alpha-hydroxy fatty acid commonly used in a variety of personal care products, especially cosmetic and skin care formulations. 2-Hydroxystearic acid has unique chemical properties that make it an effective emulsifier and stabilizer, improving the texture and shelf life of cosmetic products. It also has a potential physiological role in improving skin hydration and elasticity, although its biological function is not fully understood.

γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a polyunsaturated C₁₈ fatty acid ethyl ester, and also serves as an acyl donor in lipase-catalyzed glycerolysis reactions. γ-Linolenic acid ethyl ester undergoes glycerolysis catalyzed by the ring-substituted Candida antarctica lipase B mutant (cp283) and wild-type Candida antarctica lipase B. γ-Linolenic acid ethyl ester can be used to support the production of triglycerides required in the pharmaceutical and cosmeceutical fields.

Methyl pentadecanoate is a fatty acid ester that can be isolated from extracts of L. wallichi. Methyl pentadecanoate is formed by the condensation of the carboxyl group of pentadecanoic acid with the hydroxyl group of methanol.

Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA) and can be added into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. Ethyl arachidonate is the main species of fatty acid ethyl esters (FAEE) in brain of alcohol-intoxicated subjects.

3-Hydroxy myristic acid methyl ester (Methyl 3-hydroxytetradecanoate) is the quorum-sensing signal molecule (quormone), which regulates the virulence of Ralstonia solanacearum.

(9E,12E)-Methyl octadeca-9,12-dienoate is a methyl ester derivative of linoleic acid. (9E,12E)-Methyl octadeca-9,12-dienoate can be obtained from microalgae lipids and vegetable oils.

14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.