DDD2
DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma.
(Pink: NUDT5 ligand (HY-176262); Blue: VHL ligand (HY-120217); Black: linker (HY-W001958)).
For research use only. We do not sell to patients.
- Formula: C52H66N12O9S
- Molecular Weight:1035.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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VHL |
DDD2 (2 µM, 24 h) induces robust NUDT5 degradation in U-2 OS cells[1].
DDD2 (0.01-10 µM, 4-96 h) induces concentration- and time-dependent degradation of endogenous NUDT5 in CCRF-CEM cells[1].
DDD2 (1 µM, 24 h) degrades NUDT5 depending on VHL not CRBN in U-2 OS cells[1].
DDD2 has good solubility and stability with Kinetic Solubility Mean of 6.25 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U-2 OS cells
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Concentration:2 µM
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Incubation Time:24 h, pretreating with Doxorubicin (HY-15142A) (1 µg/mL) to induce GFP1-10
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Result:Induced robust NUDT5 degradation.
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Cell Line:CCRF-CEM cells
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Concentration:0.01, 0.03, 0.1, 0.3, 1, 3, and 10 µM
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Incubation Time:4, 24, and 96 h
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Result:Showed concentration- and time-dependent degradation of endogenous NUDT5 and achieved Dmax at 24 h.
Chemical Information
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Molecular Weight 1035.22
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Formula C52H66N12O9S
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SMILES
O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CCCCCCC(N2CCN(CC2)C3=NC4=C(C(N(C(N4C)=O)C)=O)N3CC5=NN=C(O5)C6=CC(OC)=C(C=C6)C)=O)=O)=O)NCC(C=C7)=CC=C7C(SC=N8)=C8C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DDD2 Related Classifications
HY-176261 Related Classifications
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