1481636-41-2
1481636-41-2
Chemical Structure
5-PAHSA
- CAS No.: 1481636-41-2
- Formula:C34H66O4
- Molecular Weight:538.89
IUPAC Name: 5-(palmitoyloxy)octadecanoic acid
InChIKey: QBGKCWKQYJQHJX-UHFFFAOYSA-N
SMILES: OC(CCCC(CCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCC)=O)=O
Biological Activity: 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3].
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5-PAHSA | 99.97% | 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics. | ||||||||||||||||||||
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5-PAHSA (Standard) | ≥98% | 5-PAHSA (Standard) is the analytical standard of 5-PAHSA. This product is intended for research and analytical applications. 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics. | ||||||||||||||||||||
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5-PAHSA-d9 | 5-PAHSA-d9 is the deuterium labeled 5-PAHSA (HY-116193). 5-PAHSA is a kind of anti-inflammatory and antidiabetic lipokines that connect glucose and lipid metabolism. | |||||||||||||||||||||
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5-PAHSA-d31 | 5-PAHSA-d31 is the deuterium labeled 5-PAHSA. | |||||||||||||||||||||
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References
- [1]. Wang JT, et al. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27(4):484-496. [Content Brief]
- [2]. Paluchova V, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69(3):300-312. [Content Brief]
- [3]. Wang YM, et al. High Glucose Concentration Impairs 5-PAHSA Activity by Inhibiting AMP-Activated Protein Kinase Activation and Promoting Nuclear Factor-Kappa-B-Mediated Inflammation. Front Pharmacol. 2019 Jan 7;9:1491. [Content Brief]
