hGGPPS-IN-1
hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo.
For research use only. We do not sell to patients.
- CAS No.: 1429012-38-3
- Formula: C13H13N3O6P2S
- Molecular Weight:401.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RPMI-8226 | EC50 |
>10000 nM
Compound: 18b
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Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay
Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay
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[PMID: 35077178] |
Chemical Information
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CAS No. 1429012-38-3
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Molecular Weight 401.27
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Formula C13H13N3O6P2S
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SMILES
O=P(O)(C(P(O)(O)=O)NC1=C2C=CSC2=NC(C3=CC=CC=C3)=N1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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