1429012-38-3
Chemical Structure
hGGPPS-IN-1
- CAS No.: 1429012-38-3
- Formula:C13H13N3O6P2S
- Molecular Weight:401.27
IUPAC Name: (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bis(phosphonic acid)
InChIKey: OVNNLIKSDUSVRR-UHFFFAOYSA-N
SMILES: O=P(O)(C(P(O)(O)=O)NC1=C2C=CSC2=NC(C3=CC=CC=C3)=N1)O
Biological Activity: hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
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hGGPPS-IN-1 | hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo. | |||||||||||||||||||||
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Keywords
