1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. CYP11B2-IN-1

CYP11B2-IN-1 

Cat. No.: HY-135281
Handling Instructions

CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC50 of 142 nM.

For research use only. We do not sell to patients.

CYP11B2-IN-1 Chemical Structure

CYP11B2-IN-1 Chemical Structure

CAS No. : 1356479-78-1

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Description

CYP11B2-IN-1 is a CYP11B2 inhibitor with an IC50 of 2.3 nM. CYP11B2-IN-1 inhibits CYP11B1 with an IC50 of 142 nM[1].

IC50 & Target[1]

CYP11B2

2.3 nM (IC50)

CYP11B1

142 nM (IC50)

In Vitro

CYP11B2-IN-1 (Compound 32) also inhibits CYP19 with an IC50 of 1021 nM [1] 。

In Vivo

In a rhesus pharmacodynamic model, CYP11B2-IN-1 (Compound 32) produces dose-dependent aldosterone lowering efficacy, with no apparent effect on cortisol levels[1].
CYP11B2-IN-1also displays a good rhesus pharmacokinetics profile, with low plasma clearance and acceptable oral exposure.When dosed i.v. at 0.01 and 0.3 mg/kg, CYP11B2-IN-1 produces reductions in aldosterone AUC of 62% and 95%, respectively, compared to baseline[1].

Molecular Weight

311.35

Formula

C₁₈H₁₈FN₃O

CAS No.

1356479-78-1

SMILES

OC(C)(C)C1=CC(C2=NC3=CC=C(F)C=C3N2C4CC4)=CN=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CYP11B2-IN-1Cytochrome P450CYPsbloodpressureinflammationfibrosisaldosteronesynthaseCYP11B2hypertensionInhibitorinhibitorinhibit

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CYP11B2-IN-1
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