LASS2/CerS2 Antibody (YA7072)
(Synonyms: Ceramide synthase 2 antibody; CerS 2 antibody; CerS2 antibody; CERS2_HUMAN antibody; FLJ10243 antibody; L3 antibody; LAG1 homolog ceramide synthase 2 antibody; LAG1 longevity assurance 2 antibody; LAG1 longevity assurance homolog 2 antibody; LASS 2 antibody)LASS2/CerS2 Antibody (YA7072) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LASS2/CerS2.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, ICC/IF, IHC-P
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Reactivity :
Human, Zebrafish
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Formulation:
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:500~1:1000 | 1:50~1:200 | 1:50~1:200 |
Product Details
LASS2/CerS2 Antibody (YA7072) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to LASS2/CerS2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Zebrafish
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Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 45 kDa
Synthetic peptide within Human LASS2 aa 331-380 / 380.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LASS2/CerS2 is a Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions[1][2][3][4][5][6][7][8][9].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Expressed in kidney, liver, brain, heart, placenta and lung -
Subunit
Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1 (PubMed:11543633)
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SwissProt ID
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Synonyms
Ceramide synthase 2 antibody; CerS 2 antibody; CerS2 antibody; CERS2_HUMAN antibody; FLJ10243 antibody; L3 antibody; LAG1 homolog ceramide synthase 2 antibody; LAG1 longevity assurance 2 antibody; LAG1 longevity assurance homolog 2 antibody; LASS 2 antibody
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