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Cat. No.: HY-175828

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DHPS-IN-2

DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC₅₀ of 70 nM and a K_d of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma.

For research use only. We do not sell to patients.

Formula: C₁₇H₁₅IN₂O₂
Molecular Weight:406.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DHPS-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

DHPS-IN-2 (Compound 7C16) inhibits A375 and B16 cell proliferation with IC₅₀ of 4.0 and 14.4 μM, and has a low cytotoxicity towards normal HaCaT cells (CC₅₀ = 16.6 μM)^[1].
DHPS-IN-2 (1-10 μM) significantly inhibits the invasion and migration abilities of A375 cells^[1].
DHPS-IN-2 (1-10 μM, 24 h) inhibits melanoma proliferation by modulating the expression of melanoma-associated proteins (elF5A-Hyp) in A375 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A375 cells
Concentration:

1, 5 and 10 μM
Incubation Time:

24 h
Result:

Significantly reduced the level of eIF5A-Hyp.
Reduced the melanoma markers GP-100 and tyrosinase.
Did not affect the total expression of DHPS protein.

In Vivo

DHPS-IN-2 (Compound 7C16) (15.6 μM, 7 days) exhibits potent anti-melanoma activity in zebrafish xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A375 cells were fluorescently labeled with CM-DiI and Xenograft via microinjection into the yolk sac of 2 dpf wild-type AB strain zebrafish^[1]
Dosage:

15.6 μM
Administration:

7 days
Result:

Exhibited superior antitumor efficacy at lower concentrations.

Chemical Information

Molecular Weight 406.22
Formula C₁₇H₁₅IN₂O₂
SMILES

IC1=CC=C(C=C1)CC2=NN=C(CC3=CC=CC=C3OC)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu KL, et al. In silico design, synthesis and biological evaluation of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment. Eur J Med Chem. 2025 Dec 5;299:118061. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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