1. PI3K/Akt/mTOR
    Stem Cell/Wnt
  2. GSK-3
  3. TC-G 24

TC-G 24 

Cat. No.: HY-107529
Handling Instructions

TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases.

For research use only. We do not sell to patients.

TC-G 24 Chemical Structure

TC-G 24 Chemical Structure

CAS No. : 1257256-44-2

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Description

TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases[1].

IC50 & Target

GSK-3β

17.1 nM (IC50)

In Vitro

TC-G 24 (Compound 24) binds to the ATP binding site of GSK-3β[1].
TC-G 24 (1 µM, 4 h) blocks the FBW7α-mediated degradation of TPP1 in human embryonic kidney (HEK) 293T cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: 293T cells
Concentration: 1 μM
Incubation Time: 4 h
Result: Blocked the FBW7α-mediated degradation of TPP1
In Vivo

TC-G 24 (Compound 24) (0-15 mg/kg; i.p.; once) significantly raises liver glycogen content in a dose-dependent manner without obvious toxicity and can cross the BBB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male C57BL/6N mice with weights averaging 22 g[1]
Dosage: 1, 5, and 15 mg/kg
Administration: Intraperitoneal injection, once
Result: Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).
Molecular Weight

330.73

Formula

C15H11ClN4O3

CAS No.
SMILES

O=[N+](C1=CC=C(C2=NN=C(NC3=CC=C(C)C(Cl)=C3)O2)C=C1)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TC-G 24
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HY-107529
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