XL-3156
Based on 1 Customer Validation
XL-3156 is a cGAS inhibitor. XL-3156 occupies both allosteric and orthosteric sites simultaneously, and inhibits the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of diseases such as autoimmune diseases and inflammation.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 3117797-30-2
- Formula: C28H23N9O2
- Molecular Weight:517.54
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
XL-3156 (20 μM; 20 min) inhibits the interaction between purified h-cGASCD and Cy5-labeled ISD45 DNA in EMSA assays[1].
XL-3156 (4-100 μM) dose-dependently inhibits phase separation between purified h-cGASCD and FAM-labeled ISD100 DNA in vitro[1].
XL-3156 (50 μM; 20 min) disrupts condensate formation between purified h-cGASCD and Cy3-labeled ISD100 DNA, with an EC50 of 783 nM[1].
XL-3156 (100 μM; 30 min) significantly inhibits phase separation between purified full-length h-cGASFL and Cy3-labeled ISD100 DNA in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3117797-30-2
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Appearance Solid
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Molecular Weight 517.54
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Formula C28H23N9O2
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Color White to off-white
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SMILES
CC1=NN(C(O)=C1C(C2=C(N(N=C2C)C3=NC4=CC=CC=C4N3)O)C5=NC=CC=C5)C6=NC7=CC=CC=C7N6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (96.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9322 mL | 9.6611 mL | 19.3222 mL | 48.3054 mL |
| 5 mM | 0.3864 mL | 1.9322 mL | 3.8644 mL | 9.6611 mL | |
| 10 mM | 0.1932 mL | 0.9661 mL | 1.9322 mL | 4.8305 mL | |
| 15 mM | 0.1288 mL | 0.6441 mL | 1.2881 mL | 3.2204 mL | |
| 20 mM | 0.0966 mL | 0.4831 mL | 0.9661 mL | 2.4153 mL | |
| 25 mM | 0.0773 mL | 0.3864 mL | 0.7729 mL | 1.9322 mL | |
| 30 mM | 0.0644 mL | 0.3220 mL | 0.6441 mL | 1.6102 mL | |
| 40 mM | 0.0483 mL | 0.2415 mL | 0.4831 mL | 1.2076 mL | |
| 50 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL | 0.9661 mL | |
| 60 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8051 mL | |
| 80 mM | 0.0242 mL | 0.1208 mL | 0.2415 mL | 0.6038 mL |
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