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Ly93 

Cat. No.: HY-114307
Handling Instructions

Ly93 is a selective and oral active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM.

For research use only. We do not sell to patients.

Ly93 Chemical Structure

Ly93 Chemical Structure

CAS No. : 1883528-69-5

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Description

Ly93 is a selective and oral active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1].

In Vivo

Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].
Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

Animal Model: C57BL/6J mice[1].
Dosage: 100 mg/kg.
Administration: I.G. (gavage) once daily for 7 days.
Result: Significantly decreased the plasma SM levels compared with vehicle group.
Animal Model: ApoE KO mice (eight-week-old)[1].
Dosage: 12.5 or 40 mg/kg.
Administration: I.G. (gavage) once daily.
Result: The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

332.40

Formula

C₂₁H₂₀N₂O₂

CAS No.

1883528-69-5

SMILES

O=C(NC1=CC=CN=C1)C2=CC=CC=C2OCC3=C(CC)C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ly93
Cat. No.:
HY-114307
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Ly93

Cat. No.: HY-114307