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Ly93 

Cat. No.: HY-114307
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Ly93 is a selective and oral active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM.

For research use only. We do not sell to patients.

Ly93 Chemical Structure

Ly93 Chemical Structure

CAS No. : 1883528-69-5

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Description

Ly93 is a selective and oral active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1].

In Vivo

Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].
Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

Animal Model: C57BL/6J mice[1].
Dosage: 100 mg/kg.
Administration: I.G. (gavage) once daily for 7 days.
Result: Significantly decreased the plasma SM levels compared with vehicle group.
Animal Model: ApoE KO mice (eight-week-old)[1].
Dosage: 12.5 or 40 mg/kg.
Administration: I.G. (gavage) once daily.
Result: The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.
Molecular Weight

332.40

Formula

C₂₁H₂₀N₂O₂

CAS No.

1883528-69-5

SMILES

O=C(NC1=CC=CN=C1)C2=CC=CC=C2OCC3=C(CC)C=CC=C3

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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