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Cat. No.: HY-N15159

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Cladophorol A

Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC₅₀ of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC₅₀ of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria.

For research use only. We do not sell to patients.

CAS No.: 146776-30-9
Formula: C₁₃H₈O₆
Molecular Weight:260.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Cladophorol A Chemical Structure

CAS No.: 146776-30-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

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In Vitro

Cladophorol A inhibits the cGAS-STING pathway in THP1-Lucia^TM-ISG cells with an IRF-Luc IC₅₀ of 370 nM, while exhibiting a cytotoxicity IC₅₀ >30 μM^[1].
Cladophorol-A (20 μM) enhances the stability of recombinant human cGAS protein^[1].
Cladophorol-A (0.25-100 μM) directly inhibits the catalytic activity of recombinant human cGAS^[1].
Cladophorol A (72 h) modestly inhibits asexual blood-stage Plasmodium falciparum (strain Dd2L) with an EC₅₀ of 0.7 μg/mL^[2].
Cladophorol A (18-22 h) does not inhibit the growth of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, Gram-negative pathogens, wild-type Candida albicans, or amphotericin B-resistant Candida albicans, with MIC values >50 μg/mL for all tested strains^[2].
Cladophorol A exhibits weak cytotoxicity toward HEK293T cells with a CC₅₀ of 9.4 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146776-30-9
Molecular Weight 260.20
Formula C₁₃H₈O₆
SMILES

O=C1OC2=CC(O)=C(C=C2C3=C1C=C(O)C(O)=C3)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Marine natural products
- Marine algae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kissai M, et al. Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase. Bioorg Med Chem Lett. 2025;115:130007. [Content Brief]

[2]. Lavoie S, et al. Antibacterial Oligomeric Polyphenols from the Green Alga Cladophora socialis. J Org Chem. 2019;84(9):5035-5045. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
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Cladophorol A

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cladophorol A Related Classifications

HY-N15159 Related Classifications