2. Immunology/Inflammation Anti-infection
  3. Cyclic GMP-AMP Synthase STING Parasite
  4. Cladophorol A

Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC50 of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria.

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Cladophorol A

Cladophorol A Chemical Structure

CAS No. : 146776-30-9

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Cladophorol A Related Antibodies

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Description

Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC50 of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria[1][2].

In Vitro

Cladophorol A inhibits the cGAS-STING pathway in THP1-LuciaTM-ISG cells with an IRF-Luc IC50 of 370 nM, while exhibiting a cytotoxicity IC50 >30 μM[1].
Cladophorol-A (20 μM) enhances the stability of recombinant human cGAS protein[1].
Cladophorol-A (0.25-100 μM) directly inhibits the catalytic activity of recombinant human cGAS[1].
Cladophorol A (72 h) modestly inhibits asexual blood-stage Plasmodium falciparum (strain Dd2L) with an EC50 of 0.7 μg/mL[2].
Cladophorol A (18-22 h) does not inhibit the growth of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, Gram-negative pathogens, wild-type Candida albicans, or amphotericin B-resistant Candida albicans, with MIC values >50 μg/mL for all tested strains[2].
Cladophorol A exhibits weak cytotoxicity toward HEK293T cells with a CC50 of 9.4 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cladophorol A Related Antibodies
Molecular Weight

260.20

Formula

C13H8O6
CAS No.
SMILES

O=C1OC2=CC(O)=C(C=C2C3=C1C=C(O)C(O)=C3)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Cladophorol A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cladophorol A146776-30-9Cyclic GMP-AMP SynthaseSTINGParasitecGASStimulator of Interferon GenesTMEM173MITAERISMPYSHEK293T cellshuman kidney cellscGAS-STING pathwayinflammatory diseasehuman cellsTHP1-Lucia?-ISG cellsmalariacyclic GMP-AMP synthasePlasmodium falciparumInhibitorinhibitorinhibit

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