146776-30-9
Chemical Structure
Cladophorol A
- CAS No.: 146776-30-9
- Formula:C13H8O6
- Molecular Weight:260.20
InChIKey: OSFIGXJLZQHGJN-UHFFFAOYSA-N
SMILES: O=C1OC2=CC(O)=C(C=C2C3=C1C=C(O)C(O)=C3)O
Biological Activity: Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC50 of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria[1][2].
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Cladophorol A | Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC50 of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria. | |||||||||||||||||||||
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Keywords
