2. Others Immunology/Inflammation Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Drug Metabolite Reference Standards Potassium Channel NO Synthase
  4. Rosuvastatin lactone (Standard)

Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.

For research use only. We do not sell to patients.

Rosuvastatin lactone (Standard)

Rosuvastatin lactone (Standard) Chemical Structure

CAS No. : 503610-43-3

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Information

Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

463.52

Formula

C22H26FN3O5S
CAS No.
SMILES

CC(C1=C(C(C(C=C2)=CC=C2F)=NC(N(C)[S](C)(=O)=O)=N1)/C=C/[C@@H](OC3=O)C[C@H](C3)O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Rosuvastatin lactone (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosuvastatin lactone (Standard)503610-43-3Drug MetaboliteReference StandardsPotassium ChannelNO SynthaseKcsANitric oxide synthasesNOSRosuvastatin metaboliteInhibitorinhibitorinhibit

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