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Cat. No.: HY-151421

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Chitin synthase inhibitor 11

Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs).

For research use only. We do not sell to patients.

CAS No.: 2725075-04-5
Formula: C₂₄H₂₄N₄O₈
Molecular Weight:496.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Chitin synthase inhibitor 11 Chemical Structure

CAS No.: 2725075-04-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.10 mM (chitin synthase)^[1]
MIC: 128 μg/mL (C. albicans); 42.67 μg/mL (A. flavus); 64 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)^[1]

In Vitro

Chitin synthase inhibitor 11 (compound 9s) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC₅₀ value of 0.10 mM^[1].
Chitin synthase inhibitor 11 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 128μg/mL, 42.67 μg/mL, 64 μg/mL and 64 μg/mL, respectively^[1].
Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2725075-04-5
Molecular Weight 496.47
Formula C₂₄H₂₄N₄O₈
SMILES

O=C(NC1=CC=C([N+]([O-])=O)C=C1OC)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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