SEPHS1 Protein, Human (HEK293, His)
The SEPHS1 protein catalyzes the synthesis of selenophosphate, a key step in selenium metabolism involving the conversion of selenide and ATP.This enzyme activity is the basis for selenoprotein biosynthesis and effectively promotes the incorporation of selenium into selenocysteine.SEPHS1 Protein, Human (HEK293, His) is the recombinant human-derived SEPHS1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The SEPHS1 protein catalyzes the synthesis of selenophosphate, a key step in selenium metabolism involving the conversion of selenide and ATP.This enzyme activity is the basis for selenoprotein biosynthesis and effectively promotes the incorporation of selenium into selenocysteine.SEPHS1 Protein, Human (HEK293, His) is the recombinant human-derived SEPHS1 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
The SEPHS1 protein serves as a catalyst in the synthesis of selenophosphate, a crucial step involving the conversion of selenide and ATP. This enzymatic activity demonstrates SEPHS1's pivotal role in selenium metabolism, contributing to the biosynthesis of selenoproteins. By efficiently converting selenide and ATP into selenophosphate, SEPHS1 plays a fundamental part in facilitating the incorporation of selenium into the amino acid selenocysteine, a key component of selenoproteins essential for various cellular functions. The precise enzymatic function of SEPHS1 underscores its significance in selenium homeostasis and the synthesis of biologically active selenoproteins.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
P49903 (M1-S392)
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Molecular Construction
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N-term
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SEPHS1 (M1-S392)
Accession # P49903 -
6*His
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C-term
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Protein Length
Full Length
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Synonyms
SEPHS1; SELD; Selenophosphate Synthetase 1; Selenophosphate Synthetase 1 Delta E2; SPS1; Selenophosphate Synthetase 1 Delta E8; SPS; Selenophosphate Synthetase 1 Major; Selenide, Water Dikinase 1; Selenophosphate Synthetase 1 +E9a; Selenophosphate Synthas
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AA Sequence
MSTRESFNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRLGIGMDTCVIPLRHGGLSLVQTTDYIYPIVDDPYMMGRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDRERDKVMPLIIQGFKDAAEEAGTSVTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVLVLTKPLGTQVAVAVHQWLDIPEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAHAATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLICLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRTARIIDKPRIIEVAPQVATQNVNPTPGATS
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Predicted Molecular Mass
43.9 kDa
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Molecular Weight
Approximately 42 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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