SEPHS1 - selenophosphate synthetase 1 Gene

Also Known as SPS; SELD; SPS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22929

About SEPHS1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,317,428-13,348,293 (from NCBI)

This gene has 6 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 16.5), kidney (RPKM 11.8) and 25 other tissues.

Summary

This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]

SEPHS1 Products (4)

mRNA Protein Name
NM_001195602.2 NP_001182531.1 selenide, water dikinase 1 isoform 2
NM_001195604.2 NP_001182533.1 selenide, water dikinase 1 isoform 3
NM_001375769.1 NP_001362698.1 selenide, water dikinase 1 isoform 4
NM_012247.5 NP_036379.2 selenide, water dikinase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20471958 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
20471958 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20471958 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20471958 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
20471958 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20471958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEPHS1 Protein Structure

AIRS

AIRS: AIR synthase related protein, N-terminal domain (68 - 164)

AIRS_C

AIRS_C: AIR synthase related protein, C-terminal domain (193 - 367)

  • 0
  • 100
  • 200
  • 300
  • 392 a.a.
Protein Preferred Names Protein Names

selenide, water dikinase 1

  • selenium donor protein 1

SEPHS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEPHS1 P49903 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 ZNF526 Homo sapiens Q8TF50
Validated Y2H
32296183
Intra
SEPHS1 P49903 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
Intra
SEPHS1 P49903 ZNF474 Homo sapiens Q6S9Z5
Y2H Array
32296183
Intra
SEPHS1 P49903 ZNF474 Homo sapiens Q6S9Z5
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 ZNF474 Homo sapiens Q6S9Z5
Validated Y2H
32296183
Intra
SEPHS1 P49903 QRICH1 Homo sapiens Q2TAL8
Anti Tag CoIP
33961781
Intra
SEPHS1 P49903 QRICH1 Homo sapiens Q2TAL8
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
Intra
SEPHS1 P49903 QRICH1 Homo sapiens Q2TAL8
Y2H Array
32296183
Intra
SEPHS1 P49903 XAF1 Homo sapiens Q6GPH4
Validated Y2H
32296183
Intra
SEPHS1 P49903 XAF1 Homo sapiens Q6GPH4
Y2H Array
32296183
Intra
SEPHS1 P49903 XAF1 Homo sapiens Q6GPH4
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra
SEPHS1 P49903 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra
SEPHS1 P49903 SEPHS2 Homo sapiens Q99611
Anti Tag CoIP
33961781
Intra
SEPHS1 P49903 SEPHS1 Homo sapiens P49903
Y2H Pooling
16189514
Intra
SEPHS1 P49903 ZBTB25 Homo sapiens P24278
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 ZBTB25 Homo sapiens P24278
Y2H Array
32296183
Intra
SEPHS1 P49903 SEPHS1 Homo sapiens P49903
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 SEPHS1 Homo sapiens P49903
Validated Y2H
32296183
Intra
SEPHS1 P49903 SEPHS1 Homo sapiens P49903
Y2H Array
25416956
Intra
SEPHS1 P49903 SEPHS1 Homo sapiens P49903
Y2H
21516116
Intra
SEPHS1 P49903 SEPHS1 Homo sapiens P49903
Y2H Array
32296183
Intra
SEPHS1 P49903 ZNF276 Homo sapiens Q8N554
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 ZNF276 Homo sapiens Q8N554
Validated Y2H
32296183
Intra
SEPHS1 P49903 ZNF276 Homo sapiens Q8N554
Y2H Array
32296183
Intra
SEPHS1 P49903 ZNF202 Homo sapiens O95125
Y2H Prey Pooling
32296183
Intra
SEPHS1 P49903 ZNF202 Homo sapiens O95125
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SEPHS1 Proteins

Cat. No. Product Name Accession Purity
HY-P71291 SEPHS1 Protein, Human (HEK293, His) P49903 (M1-S392) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Myopathy, Myosin Storage, Autosomal Dominant

  • MSMA

  • Myopathy, Hyaline Body, Autosomal Dominant

  • Myopathy With Lysis Of Type I Myofibrils

  • Autosomal Dominant Hyaline Body Myopathy

  • Hyaline Body Myopathy Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12678 SEPHS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18876 Sephs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25367 Sephs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SEPHS1 VGNC VGNC:46009
Felis catus SEPHS1 VGNC VGNC:65007
Macaca mulatta SEPHS1 VGNC VGNC:103863
Rattus norvegicus SEPHS1 RGD RGD:1311182
Mus musculus SEPHS1 MGD MGI:1923580
Bos taurus SEPHS1 VGNC VGNC:34448
Others SEPHS1 NCBI