1,4-PBIT dihydrobromide
Based on 1 Customer Validation
1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 157254-60-9
- Formula: C12H20Br2N4S2
- Molecular Weight:444.25
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
|
iNOS 7.6 nM (Ki) |
eNOS 360 nM (Ki) |
nNOS 16 nM (Ki) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 1, PBIT
|
Antitumor activity against human A549 cells after 24 hrs by MTS assay
Antitumor activity against human A549 cells after 24 hrs by MTS assay
|
[PMID: 20153642] |
| Caco-2 | IC50 |
59.4 μM
Compound: 1, PBIT
|
Antitumor activity against human Caco-2 cells after 72 hrs by MTS assay
Antitumor activity against human Caco-2 cells after 72 hrs by MTS assay
|
[PMID: 20153642] |
| HCT-116 | IC50 |
>100 μM
Compound: 1, PBIT
|
Antitumor activity against human HCT116 cells after 72 hrs by MTS assay
Antitumor activity against human HCT116 cells after 72 hrs by MTS assay
|
[PMID: 20153642] |
| HT-1080 | IC50 |
>100 μM
Compound: 1, PBIT
|
Antitumor activity against human HT1080 cells after 24 hrs by MTS assay
Antitumor activity against human HT1080 cells after 24 hrs by MTS assay
|
[PMID: 20153642] |
| HT-29 | IC50 |
2.4 μM
Compound: 1, PBIT
|
Antitumor activity against human HT-29 cells after 72 hrs by MTS assay
Antitumor activity against human HT-29 cells after 72 hrs by MTS assay
|
[PMID: 20153642] |
| MDA-MB-231 | IC50 |
>100 μM
Compound: 1, PBIT
|
Antitumor activity against human MDA-MB-231 cells after 24 hrs by MTS assay
Antitumor activity against human MDA-MB-231 cells after 24 hrs by MTS assay
|
[PMID: 20153642] |
| OVCAR-3 | IC50 |
>100 μM
Compound: 1, PBIT
|
Antitumor activity against human OVCAR-3 cells after 24 hrs by MTS assay
Antitumor activity against human OVCAR-3 cells after 24 hrs by MTS assay
|
[PMID: 20153642] |
| PC-3 | IC50 |
100 μM
Compound: 1, PBIT
|
Antitumor activity against human PC3 cells after 24 hrs by MTS assay
Antitumor activity against human PC3 cells after 24 hrs by MTS assay
|
[PMID: 20153642] |
| SW480 | IC50 |
16 μM
Compound: 1, PBIT
|
Antitumor activity against human SW480 cells after 72 hrs by MTS assay
Antitumor activity against human SW480 cells after 72 hrs by MTS assay
|
[PMID: 20153642] |
| WM-115 | IC50 |
>100 μM
Compound: 1, PBIT
|
Antitumor activity against human WM115 cells after 24 hrs by MTS assay
Antitumor activity against human WM115 cells after 24 hrs by MTS assay
|
[PMID: 20153642] |
Chemical Information
-
CAS No. 157254-60-9
-
Appearance Solid
-
Molecular Weight 444.25
-
Formula C12H20Br2N4S2
-
Color White to off-white
-
SMILES
NC(SCCC1=CC=C(CCSC(N)=N)C=C1)=N.[H]Br.[H]Br
-
Synonyms
1,4-PB-ITU dihydrobromide
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (264 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)