Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer

  • Bioorg Med Chem Lett. 2010 Mar 15;20(6):2038-43. doi: 10.1016/j.bmcl.2009.09.071.
Dhimant Desai  1 ,  SubbaRao V Madhunapantula ,  Krishnegowda Gowdahalli ,  Arati Sharma ,  Raghavendragowda Chandagaludoreswamy ,  Karam El-Bayoumy ,  Gavin P Robertson ,  Shantu Amin
Affiliations
  • 1. Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. [email protected]
PMID: 20153642 DOI: 10.1016/j.bmcl.2009.09.071
Abstract

Our studies demonstrate that substitution of sulfur with selenium in known iNOS Inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the Anticancer agents.