2. Apoptosis
  3. Thymidylate Synthase Apoptosis
  4. LC1343

LC1343 is a human thymidylate synthase (hTS) inhibitor with an IC50 of 7 μM. LC1343 inhibits cancer cell growth and induces apoptosis in cancer cells. LC1343 can be used for the research of ovarian cancer, colorectal cancer, and pancreatic cancer.

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LC1343

LC1343 Chemical Structure

CAS No. : 2756347-51-8

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LC1343 Related Antibodies

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Description

LC1343 is a human thymidylate synthase (hTS) inhibitor with an IC50 of 7 μM. LC1343 inhibits cancer cell growth and induces apoptosis in cancer cells. LC1343 can be used for the research of ovarian cancer, colorectal cancer, and pancreatic cancer[1][2].

In Vitro

LC1343 (72 h) potently inhibits the growth of A2780 ovarian, A2780/CP cisplatin-resistant ovarian, and HCT116 colorectal cancer cells with IC50 values of 11 μM, 18.8 μM, and 24.6 μM, respectively[1].
LC1343 (7-11 μM; 72 h with electroporation) has its cytotoxicity synergistically enhanced by electroporation in A2780 ovarian cancer cells, increasing growth inhibition from 29.5% to 62.5% at 7 μM and from 49.1% to 71.7% at 11 μM, with SQ values of 1.83 and 1.33, respectively[1].
LC1343 (5-16 μM; 72 h with electroporation) has its cytotoxicity enhanced by electroporation in A2780/CP cisplatin-resistant ovarian cancer cells, increasing growth inhibition from 24.9% to 61.7% at 5 μM and from 47.1% to 66.0% at 16 μM[1].
LC1343 (10-30 μM; 72 h with electroporation) has its cytotoxicity strongly synergistically enhanced by electroporation in HCT116 colorectal cancer cells, increasing growth inhibition from 6.1% to 35.5% at 10 μM and from 44.7% to 64.4% at 30 μM[1].
LC1343 inhibits growth of multiple cancer cell lines, including 5-FU (HY-90006)-resistant LPc167 pancreatic adenocarcinoma cells with high hTS levels, and exhibits consistent activity against PDAC-2 and PDAC-5 pancreatic adenocarcinoma cells[2].
LC1343 induces apoptotic cell death in Cisplatin (HY-17394)-sensitive A2780 and Cisplatin-resistant A2780/CP gynecological cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LC1343 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A2780 (cisplatin-sensitive ovarian carcinoma)
Concentration: 7; 11 μM
Incubation Time: 72 h (with electroporation)
Result: Caused 29.5% cell growth inhibition alone at 7 μM, which increased to 62.5% with electroporation.
Caused 49.1% cell growth inhibition alone at 11 μM, which increased to 71.7% with electroporation.

Cell Cytotoxicity Assay[1]

Cell Line: A2780/CP (cisplatin-resistant ovarian carcinoma)
Concentration: 5; 16 μM
Incubation Time: 72 h (with electroporation)
Result: Caused 24.9% cell growth inhibition alone at 5 μM, which increased to 61.7% with electroporation.
Caused 47.1% cell growth inhibition alone at 16 μM, which increased to 66.0% with electroporation.

Cell Cytotoxicity Assay[1]

Cell Line: HCT116 (colorectal adenocarcinoma)
Concentration: 10; 30 μM
Incubation Time: 72 h (with electroporation)
Result: Caused 6.1% cell growth inhibition alone at 10 μM, which increased to 35.5% with electroporation.
Caused 44.7% cell growth inhibition alone at 30 μM, which increased to 64.4% with electroporation.

Cell Cytotoxicity Assay[1]

Cell Line: A2780 (cisplatin-sensitive ovarian carcinoma), HCT116 (colorectal adenocarcinoma)
Concentration: 7; 10 μM
Incubation Time: 72 h (with electroporation)
Result: In A2780 cells, the combination with carboplatin caused 43.45% growth inhibition alone, which increased to 84.70% with electroporation.
In A2780 cells, the combination with Cisplatin caused 55.11% growth inhibition alone, which increased to 73.30% with electroporation.
In A2780 cells, the combination with Oxaliplatin (HY-17371) caused 69.30% growth inhibition alone, which increased to 82.75% with electroporation.
In HCT116 cells, the combination with Cisplatin caused 29.39% growth inhibition alone, which increased to 45.00% with electroporation.
Molecular Weight

499.58

Formula

C22H17N3O5S3
CAS No.
SMILES

O=C(NC1=NC2=CC=C(S(=O)(C)=O)C=C2S1)C(C3=CC=CC=C3)SC4=CC=C([N+]([O-])=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LC1343 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC13432756347-51-8LC 1343LC-1343Thymidylate SynthaseApoptosiscolorectal cancerovarian cancerapoptotic cell deathhuman thymidylate synthaseA2780 ovarian cancer cellsHCT116 colorectal cancer cellsgynecological cancerhTS monomer-monomer interfaceproteasomal degradationpancreatic cancerInhibitorinhibitorinhibit

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