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  3. BPH-1358 mesylate

BPH-1358 mesylate (Synonyms: NSC50460 mesylate)

Cat. No.: HY-118946B
Handling Instructions

BPH-1358 mesylate (NSC50460 mesylate) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively. BPH-1358 mesylate is active against S. aureus in vitro (MIC ~250 ng/mL).

For research use only. We do not sell to patients.

BPH-1358 mesylate Chemical Structure

BPH-1358 mesylate Chemical Structure

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Description

BPH-1358 mesylate (NSC50460 mesylate) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively. BPH-1358 mesylate is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

IC50 & Target

IC50: 1.8 μM (Human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (Undecaprenyl diphosphate synthase)[2]

In Vitro

BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

720.82

Formula

C₃₄H₃₆N₆O₈S₂

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
BPH-1358 mesylate
Cat. No.:
HY-118946B
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