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Cat. No.: HY-P84704A

HAS2 Antibody (YA4401)(PBS only)

Name: HAS2 Antibody (YA4401)(PBS only)
Brand: MedChemExpress
SKU: HY-P84704A
Availability: PreOrder

(Synonyms: Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2)

HAS2 Antibody (YA4401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS2.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-1:2000	1:200-1:1000	1:100-1:500	1:10000

Description

HAS2 Antibody (YA4401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS2.

Host Mouse
Species Reactivity
Human, Mouse, Rat, Monkey
Observed Molecular Weight

Observed band size: 64 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 64 kDa

Immunogen

Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Appearance

Solution
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

HAS2 catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan^[1]^[2]^[3]^[4]^[5].
Subcellular Localization

Cell membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Multi-pass membrane protein; Vesicle; Golgi apparatus membrane; Multi-pass membrane protein; Lysosome
Expression

Tissue_specificity:Expressed in fibroblasts

Induction:During cell cycle progression is induced at the G1-S and G2-M transitions. Up-regulated in a panel of cancer cell lines
Subunit

Homodimer; dimerization promotes enzymatic activity (PubMed:20507985, PubMed:25795779). Forms heterodimer with HAS3 (PubMed:20507985, PubMed:25795779). Forms heterodimer with HAS1 (PubMed:25795779)
SwissProt ID

Q92819
Gene ID

3037 [NCBI]
Synonyms

Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2