HAS2 Antibody (YA4401)(PBS only)

Cat. No.: HY-P84704A: Ficha de datos User Guide for Antibodies
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HAS2 Antibody (YA4401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS2.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

HAS2 Antibody (YA4401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HAS2.

Host

Mouse

Peso molecular

Predicted band size: 64 kDa;

Observed band size: 64 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat, Monkey

SwissProt ID

Q92819

Gene ID

3037 [NCBI]

Immunogen

Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-1:500
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Pureza	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer (Probable) (PubMed:20507985, PubMed:21228273, PubMed:23303191, PubMed:32993960). Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (PubMed:20507985, PubMed:21228273, PubMed:8798477). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Multi-pass membrane protein; Vesicle; Golgi apparatus membrane; Multi-pass membrane protein; Lysosome

Expression：
Tissue_specificity:Expressed in fibroblasts

Induction:During cell cycle progression is induced at the G1-S and G2-M transitions. Up-regulated in a panel of cancer cell lines

Subunit：Homodimer; dimerization promotes enzymatic activity (PubMed:20507985, PubMed:25795779). Forms heterodimer with HAS3 (PubMed:20507985, PubMed:25795779). Forms heterodimer with HAS1 (PubMed:25795779)

Synonyms

Hyaluronan synthase 2, Hyaluronate synthase 2, Hyaluronic acid synthase 2, HA synthase 2, HAS2

Documentación

User Guide for Antibodies (1077 KB)