2. NF-κB Immunology/Inflammation
  3. NF-κB NO Synthase
  4. Neocryptotanshinone

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.

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Neocryptotanshinone Chemical Structure

Neocryptotanshinone Chemical Structure

CAS No. : 109664-02-0

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Based on 1 publication(s) in Google Scholar

Neocryptotanshinone Related Antibodies

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  • Biological Activity

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Description

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

IC50 & Target

iNOS

 

In Vitro

Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways[1].
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells[1].
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neocryptotanshinone Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW264.7 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Inhibited LPS-induced cell viability in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Inhibited LPS-induced activation of NF-κB pathway and down-regulated LPS-induced expression of p-NF-κB p65, p-IκBα and p-IKKβ.
In Vivo

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MSU-induced pain model in male ICR mice (weighing 20-25 g)[2]
Dosage: 10, 25, 50 or 100 mg/kg
Administration: Oral gavage; for 30, 60, 120 min
Result: Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.
Molecular Weight

314.38

Formula

C19H22O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C([C@@H](C)CO)=C(O)C(C2=C1C=CC3=C2CCCC3(C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (318.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1809 mL 15.9043 mL 31.8086 mL
5 mM 0.6362 mL 3.1809 mL 6.3617 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.82%

COA (249 KB) HNMR (154 KB) RP-HPLC (244 KB) MS (78 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1809 mL 15.9043 mL 31.8086 mL 79.5216 mL
5 mM 0.6362 mL 3.1809 mL 6.3617 mL 15.9043 mL
10 mM 0.3181 mL 1.5904 mL 3.1809 mL 7.9522 mL
15 mM 0.2121 mL 1.0603 mL 2.1206 mL 5.3014 mL
20 mM 0.1590 mL 0.7952 mL 1.5904 mL 3.9761 mL
25 mM 0.1272 mL 0.6362 mL 1.2723 mL 3.1809 mL
30 mM 0.1060 mL 0.5301 mL 1.0603 mL 2.6507 mL
40 mM 0.0795 mL 0.3976 mL 0.7952 mL 1.9880 mL
50 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5904 mL
60 mM 0.0530 mL 0.2651 mL 0.5301 mL 1.3254 mL
80 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9940 mL
100 mM 0.0318 mL 0.1590 mL 0.3181 mL 0.7952 mL
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Neocryptotanshinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neocryptotanshinone109664-02-0NF-κBNO SynthaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSInflammationInducible nitric oxide synthaseSalvia miltiorrhizalipopolysaccharidesnitric oxideInhibitorinhibitorinhibit

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