Leukotriene A4 methyl ester
Based on 1 publication(s) in Google Scholar
Leukotriene A4 methyl ester (LTA4 methyl ester) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
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- CAS No.: 73466-12-3
- 화학식: C21H32O3
- 분자량:332.48
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보관:
Solution, -20°C, 2 years
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) Leukotriene A4 methyl ester
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Biological Activity
Chemical Information
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CAS No. 73466-12-3
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Appearance Liquid
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분자량 332.48
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화학식 C21H32O3
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Color Colorless to light yellow
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SMILES
O=C(OC)CCC[C@@H]1O[C@H]1/C=C/C=C/C=C\C/C=C\CCCCC
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Synonyms
LTA4 methyl ester
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase. [Abstract]2023 Apr 19;24(8):7539. PMID: 37108702
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leukotriene A4 methyl ester Related Classifications
HY-112621 Related Classifications
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