cGAS-IN-8
cGAS-IN-8 is an indazole cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 6 nM for human cGAS. cGAS-IN-8 inhibits cGAMP production in THP-1 cells with an IC50 of 0.12 µM. cGAS-IN-8 does not inhibits hERG activity. cGAS-IN-8 can be used for the research of autoimmune diseases.
For research use only. We do not sell to patients.
- Formula: C18H18ClF4N5O4
- Molecular Weight:479.81
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Parmacokinetics
| Species | Dose | Route | CL | Vss | T1/2 | F |
|---|---|---|---|---|---|---|
| Mice | 0.5 mg/kg | i.v. | 10.4 mL/min/kg | 1.3 L/kg | 2.1 h | 111 % |
| Mice | 5 mg/kg | p.o. | 10.4 mL/min/kg | 1.3 L/kg | 2.1 h | 111 % |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 479.81
-
Formula C18H18ClF4N5O4
-
SMILES
N#CCNCC(N1[C@@H](C)C2=C3C=C(OC)C(Cl)=C(F)C3=NN2CC1)=O.O=C(O)C(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cGAS-IN-8 Related Classifications
HY-180211 Related Classifications
Powered by Bioz