cGAS-IN-8
cGAS-IN-8 is an indazole cyclic GMP-AMP synthase (cGAS) inhibitor with an IC50 of 6 nM for human cGAS. cGAS-IN-8 inhibits cGAMP production in THP-1 cells with an IC50 of 0.12 µM. cGAS-IN-8 does not inhibits hERG activity. cGAS-IN-8 can be used for the research of autoimmune diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C18H18ClF4N5O4
- Masse moléculaire:479.81
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
In Vitro
Parmacokinetics
| Species | Dose | Route | CL | Vss | T1/2 | F |
|---|---|---|---|---|---|---|
| Mice | 0.5 mg/kg | i.v. | 10.4 mL/min/kg | 1.3 L/kg | 2.1 h | 111 % |
| Mice | 5 mg/kg | p.o. | 10.4 mL/min/kg | 1.3 L/kg | 2.1 h | 111 % |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Masse moléculaire 479.81
-
Formule C18H18ClF4N5O4
-
SMILES
N#CCNCC(N1[C@@H](C)C2=C3C=C(OC)C(Cl)=C(F)C3=NN2CC1)=O.O=C(O)C(F)(F)F
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
cGAS-IN-8 Related Classifications
HY-180211 Related Classifications
Powered by Bioz