Cat. No.: HY-113216

Asymmetric dimethylarginine

(Synonyms: NG,NG-Dimethylarginine)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.

For research use only. We do not sell to patients.

Purity: 99.9%
CAS No.: 30315-93-6
Formula: C₈H₁₈N₄O₂
Molecular Weight:202.25

Storage:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Asymmetric dimethylarginine Chemical Structure

CAS No.: 30315-93-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All NO Synthase Isoforms :

In Vitro

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Asymmetric dimethylarginine (ADMA) is elevated in HIV-1 infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 30315-93-6
Appearance Solid
Molecular Weight 202.25
Formula C₈H₁₈N₄O₂
Color White to off-white
SMILES

CN(C)C(NCCC[C@H](N)C(O)=O)=N
Synonyms

NG,NG-Dimethylarginine
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Publications (5)

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Cell Metab

Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis. [Abstract]

2025 Oct 10:S1550-4131(25)00434-6. PMID: 41075780
Cell Metab

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology. [Abstract]

2025 Jan 7;37(1):291-304.e9. PMID: 39413790
Cell Death Dis

DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson's disease. [Abstract]

2024 Jun 7;15(6):399. PMID: 38849335
EMBO Rep

Tudor-based proteomic strategy pan-specifically enriches and identifies protein arginine methylation. [Abstract]

2025 Oct 20. PMID: 41116072
Int J Mol Sci

The Regulatory Impact of CFLAR Methylation Modification on Liver Lipid Metabolism. [Abstract]

2024 Jul 19;25(14):7897. PMID: 39063139

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (494.44 mM; Need ultrasonic)

DMSO : 100 mg/mL (494.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.9444 mL

24.7219 mL

49.4438 mL

5 mM

0.9889 mL

4.9444 mL

9.8888 mL

10 mM

0.4944 mL

2.4722 mL

4.9444 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (494.44 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hudson CL, et al. The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression. Ann Clin Biochem. 2014 Sep;51(Pt 5):568-75. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	4.9444 mL	24.7219 mL	49.4438 mL	123.6094 mL
	5 mM	0.9889 mL	4.9444 mL	9.8888 mL	24.7219 mL
	10 mM	0.4944 mL	2.4722 mL	4.9444 mL	12.3609 mL
	15 mM	0.3296 mL	1.6481 mL	3.2963 mL	8.2406 mL
	20 mM	0.2472 mL	1.2361 mL	2.4722 mL	6.1805 mL
	25 mM	0.1978 mL	0.9889 mL	1.9778 mL	4.9444 mL
	30 mM	0.1648 mL	0.8241 mL	1.6481 mL	4.1203 mL
	40 mM	0.1236 mL	0.6180 mL	1.2361 mL	3.0902 mL
	50 mM	0.0989 mL	0.4944 mL	0.9889 mL	2.4722 mL
	60 mM	0.0824 mL	0.4120 mL	0.8241 mL	2.0602 mL
	80 mM	0.0618 mL	0.3090 mL	0.6180 mL	1.5451 mL
	100 mM	0.0494 mL	0.2472 mL	0.4944 mL	1.2361 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Asymmetric dimethylarginine

5 Cited Publications

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Asymmetric dimethylarginine

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Publications Citing Use of MedChemExpress (MCE) Asymmetric dimethylarginine

All Endogenous Metabolite Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Asymmetric dimethylarginine Related Classifications

HY-113216 Related Classifications