Asymmetric dimethylarginine dihydrochloride (Synonyms: NG,NG-Dimethylarginine dihydrochloride)

Cat. No.: HY-113216B: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Asymmetric dimethylarginine dihydrochloride is an endogenous NO synthase inhibitor that reduces NO production, which contributes to endothelial dysfunction and cardiovascular disease.

For research use only. We do not sell to patients.

Asymmetric dimethylarginine dihydrochloride Chemical Structure

CAS No. : 220805-22-1

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Other In-stock Forms of Asymmetric dimethylarginine dihydrochloride:

Asymmetric dimethylarginine

Other Forms of Asymmetric dimethylarginine dihydrochloride:

Asymmetric-dimethylarginine-d₆ dihydrochloride In-stock
Asymmetric dimethylarginine In-stock

5 Publications Citing Use of MCE Asymmetric dimethylarginine dihydrochloride

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nNOS iNOS eNOS

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Purity & Documentation
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Description

Asymmetric dimethylarginine dihydrochloride is an endogenous NO synthase inhibitor that reduces NO production, which contributes to endothelial dysfunction and cardiovascular disease^[1].

Molecular Weight

275.18

Formula

C₈H₂₀Cl₂N₄O₂

CAS No.

220805-22-1

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.[H]Cl.CN(C)C(NCCC[C@H](N)C(O)=O)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (363.40 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6340 mL	18.1699 mL	36.3399 mL
5 mM	0.7268 mL	3.6340 mL	7.2680 mL
10 mM	0.3634 mL	1.8170 mL	3.6340 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Latika Sibal, et al. The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease. Curr Cardiol Rev. 2010 May;6(2):82-90.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.6340 mL	18.1699 mL	36.3399 mL	90.8496 mL
	5 mM	0.7268 mL	3.6340 mL	7.2680 mL	18.1699 mL
	10 mM	0.3634 mL	1.8170 mL	3.6340 mL	9.0850 mL
	15 mM	0.2423 mL	1.2113 mL	2.4227 mL	6.0566 mL
	20 mM	0.1817 mL	0.9085 mL	1.8170 mL	4.5425 mL
	25 mM	0.1454 mL	0.7268 mL	1.4536 mL	3.6340 mL
	30 mM	0.1211 mL	0.6057 mL	1.2113 mL	3.0283 mL
	40 mM	0.0908 mL	0.4542 mL	0.9085 mL	2.2712 mL
	50 mM	0.0727 mL	0.3634 mL	0.7268 mL	1.8170 mL
	60 mM	0.0606 mL	0.3028 mL	0.6057 mL	1.5142 mL
	80 mM	0.0454 mL	0.2271 mL	0.4542 mL	1.1356 mL
	100 mM	0.0363 mL	0.1817 mL	0.3634 mL	0.9085 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Asymmetric dimethylarginine dihydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asymmetric dimethylarginine220805-22-1NG,NG-DimethylarginineNO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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