PTIO
Based on 1 publication(s) in Google Scholar
PTIO is a specific scavenger of NO and redox mediator. PTIO reacts with •NO to form the corresponding imino nitroxides and •NO2. PTIO enhances organic contaminants oxidation by permanganate.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 18390-00-6
- Formula: C13H17N2O2
- Molecular Weight:233.29
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PTIO
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | EC50 |
51.63 μM
Compound: 1
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Hydrogen peroxide radical scavenging activity in PC12 cell by survival assay
Hydrogen peroxide radical scavenging activity in PC12 cell by survival assay
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[PMID: 17306423] |
| PC-12 | EC50 |
66.51 μM
Compound: 1
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Hydroxyl radical scavenging activity in PC12 cell by survival assay
Hydroxyl radical scavenging activity in PC12 cell by survival assay
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[PMID: 17306423] |
| PC-12 | EC50 |
67.61 μM
Compound: 1
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Nitric oxide radical scavenging activity in PC12 cells by survival assay
Nitric oxide radical scavenging activity in PC12 cells by survival assay
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[PMID: 17306423] |
PTIO combined with Mn(VII) effectively removes BPA[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18390-00-6
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Appearance Solid
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Molecular Weight 233.29
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Formula C13H17N2O2
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Color Brown to black
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SMILES
[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 166.67 mg/mL (714.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Xia JL , et al. Putrescine regulates nitric oxide accumulation in Ganoderma lucidum partly by influencing cellular glutamine levels under heat stress. Microbiol Res. 2020;239:126521. [Content Brief]
[2]. Goldstein S, et al. Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*. J Biol Chem. 2003;278(51):50949-50955. [Content Brief]
[3]. Zhao L, et al. PTIO as a redox mediator to enhance organic contaminants oxidation by permanganate. Water Res. 2023 Oct 1;244:120500. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2865 mL | 21.4326 mL | 42.8651 mL | 107.1628 mL |
| 5 mM | 0.8573 mL | 4.2865 mL | 8.5730 mL | 21.4326 mL | |
| 10 mM | 0.4287 mL | 2.1433 mL | 4.2865 mL | 10.7163 mL | |
| 15 mM | 0.2858 mL | 1.4288 mL | 2.8577 mL | 7.1442 mL | |
| 20 mM | 0.2143 mL | 1.0716 mL | 2.1433 mL | 5.3581 mL | |
| 25 mM | 0.1715 mL | 0.8573 mL | 1.7146 mL | 4.2865 mL | |
| 30 mM | 0.1429 mL | 0.7144 mL | 1.4288 mL | 3.5721 mL | |
| 40 mM | 0.1072 mL | 0.5358 mL | 1.0716 mL | 2.6791 mL | |
| 50 mM | 0.0857 mL | 0.4287 mL | 0.8573 mL | 2.1433 mL | |
| 60 mM | 0.0714 mL | 0.3572 mL | 0.7144 mL | 1.7860 mL | |
| 80 mM | 0.0536 mL | 0.2679 mL | 0.5358 mL | 1.3395 mL | |
| 100 mM | 0.0429 mL | 0.2143 mL | 0.4287 mL | 1.0716 mL |
PTIO Related Classifications
HY-131898 Related Classifications
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