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Cat. No.: HY-151419

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Chitin synthase inhibitor 9

Chitin synthase inhibitor 9 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection.

For research use only. We do not sell to patients.

CAS No.: 2725074-96-2
Formula: C₂₄H₂₅N₃O₆
Molecular Weight:451.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Chitin synthase inhibitor 9 Chemical Structure

CAS No.: 2725074-96-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Chitin synthase inhibitor 9 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection^[1].

IC₅₀ & Target

Chitin synthase^[1]

In Vitro

Chitin synthase inhibitor 9 (compound 9j, 300 μg/mL) inhibits chitin synthase (CHS) by 60%^[1].
Chitin synthase inhibitor 9 (0.0625-0.25 μM, 24 h) shows antifungal activities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C. albicans, A. flavus, A. fumigatus, C. neoformans
Concentration:

1-512 μg/mL
Incubation Time:

1-512 μg/mL
Result:

Inhibited four fungi with IC₅₀ value of 64, 128, 128, 256 μg/mL respectively.

Chemical Information

CAS No. 2725074-96-2
Molecular Weight 451.47
Formula C₂₄H₂₅N₃O₆
SMILES

O=C(NC1=CC=CC=C1OC)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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